Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells.

@article{Fazal2009EssentialRO,
  title={Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells.},
  author={Fabeha Fazal and Kaiser M. Bijli and Mohd Minhajuddin and Theo Rein and Jacob N. Finkelstein and Arshad Rahman},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 31},
  pages={21047-56}
}
Activation of RhoA/Rho-associated kinase (ROCK) pathway and the associated changes in actin cytoskeleton induced by thrombin are crucial for activation of NF-kappaB and expression of its target gene ICAM-1 in endothelial cells. However, the events acting downstream of RhoA/ROCK to mediate these responses remain unclear. Here, we show a central role of cofilin-1, an actin-binding protein that promotes actin depolymerization, in linking RhoA/ROCK pathway to dynamic alterations in actin… CONTINUE READING

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