Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells.

@article{Takami2006EssentialRO,
  title={Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells.},
  author={Yasunari Takami and Takafumi Ono and Tatsuo Fukagawa and Kei-ichi Shibahara and Tatsuo Nakayama},
  journal={Molecular biology of the cell},
  year={2006},
  volume={18 1},
  pages={
          129-41
        }
}
Chromatin assembly factor-1 (CAF-1), a complex consisting of p150, p60, and p48 subunits, is highly conserved from yeast to humans and facilitates nucleosome assembly of newly replicated DNA in vitro. To investigate roles of CAF-1 in vertebrates, we generated two conditional DT40 mutants, respectively, devoid of CAF-1p150 and p60. Depletion of each of these CAF-1 subunits led to delayed S-phase progression concomitant with slow DNA synthesis, followed by accumulation in late S/G2 phase and… CONTINUE READING

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