Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability: determinants of the vascular leak site.

@article{Wu2005EssentialRO,
  title={Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability: determinants of the vascular leak site.},
  author={Songwei Wu and Eugene A. Cioffi and Diego Iglesias Alvarez and Sarah L. Sayner and Hairu Chen and Donna L. Cioffi and Judy King and Judy R. Creighton and Mary I. Townsley and Steven R. Goodman and Troy Stevens},
  journal={Circulation research},
  year={2005},
  volume={96 8},
  pages={856-63}
}
Store-operated calcium (SOC) entry is sufficient to disrupt the extra-alveolar, but not the alveolar, endothelial cell barrier. Mechanism(s) underlying such insensitivity to transitions in cytosolic calcium ([Ca2+]i) in microvascular endothelial cells are unknown. Depletion of stored Ca2+ activates a larger SOC entry response in extra-alveolar (pulmonary artery; PAECs) than alveolar (pulmonary microvascular; PMVECs) endothelial cells. In vivo permeation studies revealed that Ca2+ store… CONTINUE READING

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