Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.

  title={Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.},
  author={Sudarshan Anand and Pu Patrick Wang and Kiyoshi Yoshimura and I. Choi and Anja Hilliard and Youhai H Chen and Chyung-Ru Wang and Richard David Schulick and Andrew S. Flies and Dallas B. Flies and Gefeng Zhu and Yanhui Xu and Drew Mark Pardoll and Lieping Chen and Koji Tamada},
  journal={The Journal of clinical investigation},
  volume={116 4},
LIGHT is an important costimulatory molecule for T cell immunity. Recent studies have further implicated its role in innate immunity and inflammatory diseases, but its cellular and molecular mechanisms remain elusive. We report here that LIGHT is upregulated and functions as a proinflammatory cytokine in 2 independent experimental hepatitis models, induced by concanavalin A and Listeria monocytogenes. Molecular mutagenesis studies suggest that soluble LIGHT protein produced by cleavage from the… CONTINUE READING
29 Citations
17 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 29 extracted citations


Publications referenced by this paper.
Showing 1-10 of 17 references

Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

  • S Scheu
  • J. Exp. Med
  • 2002

Similar Papers

Loading similar papers…