Essential role of TAK1 in regulating mantle cell lymphoma survival.

  title={Essential role of TAK1 in regulating mantle cell lymphoma survival.},
  author={Daniela Buglio and Sangeetha Palakurthi and Kate F. Byth and Francisco de la Vega and Dorin Toader and Jamal C. Saeh and Sattva S. Neelapu and Anas Younes},
  volume={120 2},
TGF-β-activated kinase 1 (TAK1), a member of the MAPK kinase family, plays a key role in B-cell growth and development. In the present study, we examined the potential role of TAK1 as a therapeutic target for lymphoma. Here, we show that the active phosphorylated form of TAK1 is abundantly expressed in a panel of lymphoma cell lines, including mantle cell, anaplastic large cell, and Hodgkin lymphoma cell lines. Silencing TAK1 expression via the use of siRNA inhibited the activation of NF-κB and… CONTINUE READING
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