Essential role of Sox2 for the establishment and maintenance of the germ cell line.

  title={Essential role of Sox2 for the establishment and maintenance of the germ cell line.},
  author={Federica Campolo and Manuele Gori and Rebecca Favaro and Silvia K Nicolis and Manuela Pellegrini and Flavia Botti and Pellegrino Rossi and Emmanuele A Jannini and Susanna Dolci},
  journal={Stem cells},
  volume={31 7},
Sox2 is a pluripotency-conferring gene expressed in primordial germ cells (PGCs) and postnatal oocytes, but the role it plays during germ cell development and early embryogenesis is unknown. Since Sox2 ablation causes early embryonic lethality shortly after blastocyst implantation, we generated mice bearing Sox2-conditional deletion in germ cells at different stages of their development through the Cre/loxP recombination system. Embryos lacking Sox2 in PGCs show a dramatic decrease of germ cell… CONTINUE READING


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