Essential role of Sox2 for the establishment and maintenance of the germ cell line.

@article{Campolo2013EssentialRO,
  title={Essential role of Sox2 for the establishment and maintenance of the germ cell line.},
  author={Federica Campolo and Manuele Gori and Rebecca Favaro and Silvia K Nicolis and Manuela Pellegrini and Flavia Botti and Pellegrino Rossi and Emmanuele A Jannini and Susanna Dolci},
  journal={Stem cells},
  year={2013},
  volume={31 7},
  pages={1408-21}
}
Sox2 is a pluripotency-conferring gene expressed in primordial germ cells (PGCs) and postnatal oocytes, but the role it plays during germ cell development and early embryogenesis is unknown. Since Sox2 ablation causes early embryonic lethality shortly after blastocyst implantation, we generated mice bearing Sox2-conditional deletion in germ cells at different stages of their development through the Cre/loxP recombination system. Embryos lacking Sox2 in PGCs show a dramatic decrease of germ cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells

Cell reports • 2018
View 4 Excerpts
Highly Influenced

Regulation of pluripotency in male germline stem cells by Dmrt1.

Genes & development • 2013
View 1 Excerpt
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…