Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.

@article{Hagihara2005EssentialRO,
  title={Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.},
  author={Keisuke Hagihara and Teppei Nishikawa and Yasuhiro Sugamata and Jian Song and Tomoyasu Isobe and Tetsuya Taga and Kazuyuki Yoshizaki},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2005},
  volume={10 11},
  pages={1051-63}
}
Serum amyloid A (SAA) is a sensitive marker of acute-phase responses and known as a precursor protein of amyloid fibril in amyloid A (AA) (secondary) amyloidosis. Since the serum SAA level is also closely related to activity of chronic inflammatory disease and coronary artery disease, it is important to clarify the exact induction mechanism of SAA from the clinical point of view. Here we provide evidence that STAT3 plays an essential role in cytokine-driven SAA expression, although the human… CONTINUE READING