Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.

@article{Durn2003EssentialRO,
  title={Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.},
  author={Angeles Dur{\'a}n and Mar{\'i}a Teresa D{\'i}az-Meco and Jorge Moscat},
  journal={The EMBO journal},
  year={2003},
  volume={22 15},
  pages={3910-8}
}
The activation of the transcription factor NF-kappaB is central to the control of the cellular response triggered by many stimuli. Once released from the inhibitory molecule IkappaB, NF-kappaB is translocated to the nucleus, and it has to be phosphorylated to activate transcription. In zeta protein kinase C (PKC)-deficient cells, NF-kappaB is transcriptionally inactive and the phosphorylation of the RelA subunit in response to tumor necrosis factor (TNF-alpha) is severely impaired. In vitro… CONTINUE READING
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