Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.

@article{Nguyen2006EssentialRO,
  title={Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo.},
  author={Kinh-Tung T. Nguyen and Panteha Tajmir and Chia Hung Lin and Nicole Liadis and Xu-Dong Zhu and Mohammed Eweida and Gunce Tolasa-Karaman and Fang Cai and Rennian Wang and Tadahiro Kitamura and Denise D Belsham and Michael B Wheeler and Akira K. Suzuki and Tak W Mak and Minna Woo},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 12},
  pages={
          4511-8
        }
}
PTEN (phosphatase with tensin homology) is a potent negative regulator of phosphoinositide 3-kinase (PI3K)/Akt signaling, an evolutionarily conserved pathway that signals downstream of growth factors, including insulin and insulin-like growth factor 1. In lower organisms, this pathway participates in fuel metabolism and body size regulation and insulin-like proteins are produced primarily by neuronal structures, whereas in mammals, the major source of insulin is the pancreatic beta cells… CONTINUE READING
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