Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

@article{Lee2009EssentialRO,
  title={Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance},
  author={Tae Ho Lee and Adrian Tun-Kyi and Rong Shi and Jormay Lim and Christina Y Soohoo and Greg Finn and Martin Balastik and Lucia Pastorino and Gerburg M Wulf and Xiao Zhen Zhou and Kun Lu},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={97-105}
}
Telomeres are essential for maintaining cellular proliferative capacity and their loss has been implicated in ageing. A key regulator in telomere maintenance is the telomeric protein TRF1, which was also identified as Pin2 in a screen for Pin1. Pin1 is a unique prolyl isomerase that regulates protein conformation and function after phosphorylation. However, little is known about the role of Pin1 in telomere regulation or the modulation of TRF1 by upstream signals. Here we identify TRF1 as a… CONTINUE READING

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