Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury.

@article{Parmentier2006EssentialRO,
  title={Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury.},
  author={J H Parmentier and Chunxiang Zhang and Anne M. Estes and Susan A Schaefer and Kafait U. Malik},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 4},
  pages={H1602-13}
}
The contribution of atypical protein kinase C (PKC)-zeta to ANG II-accelerated restenosis after endoluminal vascular injury was investigated by using the rat carotid balloon injury model. Exposure of injured arteries to ANG II resulted in an extensive neointimal thickening (1.9 times) compared with vehicle at day 14. Treatment with PKC-zeta antisense, but not scrambled, oligonucleotides reduced neointimal formation observed in the presence or absence of ANG II. Examination of early events (2… CONTINUE READING

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