Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis.

@article{Tsutsumi2004EssentialRO,
  title={Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis.},
  author={Norifumi Tsutsumi and Yoshikazu Yonemitsu and Yasunori Shikada and Mitsuho Onimaru and Mitsugu Tanii and Shinji Okano and Kazuhiro Kaneko and Mamoru Hasegawa and Makoto Hashizume and Yoshihiko Maehara and Katsuo Sueishi},
  journal={Circulation research},
  year={2004},
  volume={94 9},
  pages={1186-94}
}
Discovery of the common and ubiquitous molecular targets for the disruption of angiogenesis, that are independent of the characteristics of malignant tumors, is desired to develop the more effective antitumor drugs. In this study, we propose that the platelet-derived growth factor receptor-alpha (PDGFRalpha)-p70S6K signal transduction pathway in mesenchymal cells, which is required for functional angiogenesis induced by fibroblast growth factor-2, is the potent candidate. Using murine limb… CONTINUE READING

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