Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory.

@article{Xu2012EssentialRO,
  title={Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory.},
  author={Ya Fei Xu and Xiu-Fang Lv and Cai-lian Cui and Fei-fei Ge and Yi-Jing Li and Hao-Lin Zhang},
  journal={Brain research bulletin},
  year={2012},
  volume={89 1-2},
  pages={22-30}
}
Learned associations between the rewarding effect of addictive drugs and drug-paired contexts resist extinction and contribute to the high rate of relapse observed in drug addicts. Although it has been shown that extracellular signal-regulated kinase 1/2 (ERK1/2) activity in the nucleus accumbens (NAc) is modulated by the primary rewarding effect of opiates, little is known as to its role in the morphine-associated contextual memory. In the present study, we investigated the ERK1/2 activity… CONTINUE READING

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