Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

@article{Hailfinger2009EssentialRO,
  title={Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.},
  author={Stephan Hailfinger and Georg Lenz and Vu N. Ngo and Anita Posvitz-Fejfar and Fabien Rebeaud and Montserrat Guzzardi and Eva-Maria Murga Penas and Judith Dierlamm and Wing Chung Chan and Louis M. Staudt and M Thome},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 47},
  pages={19946-51}
}
A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse large B-cell lymphoma (DLBCL) of the activated B-cell (ABC) subtype, the least curable subtype of DLBCL. Recent data suggest that MALT1 has proteolytic activity, but it is unknown whether this activity… CONTINUE READING

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