Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

@article{Dong2009EssentialRO,
  title={Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases},
  author={Jin-Tang Dong and Ceshi Chen},
  journal={Cellular and Molecular Life Sciences},
  year={2009},
  volume={66},
  pages={2691-2706}
}
KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a number of gene promoters and regulating their transcription. KLF5 is expressed during development and, in adults, with higher levels in proliferating epithelial cells. The expression and activity of KLF5 are regulated by multiple signaling pathways, including Ras/MAPK, PKC, and TGFβ, and various posttranslational modifications, including phosphorylation, acetylation, ubiquitination, and sumoylation… CONTINUE READING
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