Essential role of Gap junctions in NO- and prostanoid-independent relaxations evoked by acetylcholine in rabbit intracerebral arteries.

@article{Ujiie2003EssentialRO,
  title={Essential role of Gap junctions in NO- and prostanoid-independent relaxations evoked by acetylcholine in rabbit intracerebral arteries.},
  author={Hiroshi Ujiie and Andrew T Chaytor and Linda M Bakker and Tudor M. Griffith},
  journal={Stroke},
  year={2003},
  volume={34 2},
  pages={
          544-50
        }
}
BACKGROUND AND PURPOSE Direct intercellular communication via gap junctions may play a central role in endothelium-dependent relaxations that are mediated by a conducted hyperpolarization and do not involve the synthesis of NO and prostanoids. In the present study, inhibitory peptides homologous to the Gap27 domain of the second extracellular loop of connexin37/connexin43 and connexin40, designated as 37,43Gap27 and 40Gap27, respectively, were used to evaluate the role of this mechanism in… CONTINUE READING
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