Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.

@article{Crackower2003EssentialRO,
  title={Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.},
  author={Michael A. Crackower and Nadine K. Kolas and Junko Noguchi and Renu Sarao and Kazuhiro Kikuchi and Hiroyuki Kaneko and Eiji Kobayashi and Yasuhiro Kawai and Ivona Kozieradzki and Rushin Landers and Rong Qing Mo and Chi-Chung Hui and Edward Nieves and Paula E. Cohen and Lucy R. Osborne and Teiji Wada and Tetsuo Kunieda and Peter B. Moens and Josef M. Penninger},
  journal={Science},
  year={2003},
  volume={300 5623},
  pages={1291-5}
}
Meiosis is a critical stage of gametogenesis in which alignment and synapsis of chromosomal pairs occur, allowing for the recombination of maternal and paternal genomes. Here we show that FK506 binding protein (Fkbp6) localizes to meiotic chromosome cores and regions of homologous chromosome synapsis. Targeted inactivation of Fkbp6 in mice results in aspermic males and the absence of normal pachytene spermatocytes. Moreover, we identified the deletion of Fkbp6 exon 8 as the causative mutation… CONTINUE READING

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