Essential role of Dkk3 for head formation by inhibiting Wnt/β-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus.

@article{Onai2012EssentialRO,
  title={Essential role of Dkk3 for head formation by inhibiting Wnt/β-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus.},
  author={Takayuki Onai and Akira Takai and Davin H. E. Setiamarga and Linda Z Holland},
  journal={Evolution & development},
  year={2012},
  volume={14 4},
  pages={
          338-50
        }
}
To dissect the molecular mechanism of head specification in the basal chordate amphioxus, we investigated the function of Dkk3, a secreted protein in the Dickkopf family, which is expressed anteriorly in early embryos. Amphioxus Dkk3 has three domains characteristic of Dkk3 proteins-an N-terminal serine rich domain and two C-terminal cysteine-rich domains (CRDs). In addition, amphioxus Dkk3 has a TGFβ-receptor 2 domain, which is not present in Dkk3 proteins of other species. As vertebrate Dkk3… CONTINUE READING
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Metamerism in cephalochordates and the problem of the vertebrate head.

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