Essential role of B-Raf in ERK activation during extraembryonic development.

  title={Essential role of B-Raf in ERK activation during extraembryonic development.},
  author={Gergana Galabova-Kovacs and Dana Matzen and Daniela Piazzolla and Katrin Meissl and Tatiana Plyushch and Adele Pin Chen and Alcino Lazaro da Silva and Manuela Baccarini},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 5},
The kinases of the Raf family have been intensively studied as activators of the mitogen-activated protein kinase kinase/extra-cellular signal-regulated kinase (ERK) module in regulated and deregulated proliferation. Genetic evidence that Raf is required for ERK activation in vivo has been obtained in lower organisms, which express only one Raf kinase, but was hitherto lacking in mammals, which express more than one Raf kinase. Ablation of the two best studied Raf kinases, B-Raf and Raf-1, is… CONTINUE READING


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Development (Cambridge, U.K

  • L. B. Corson, Y. Yamanaka, K. M. Lai, J. Rossant
  • 2003

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