Essential role of ATP synthesized by creatine kinase in contraction of alpha-toxin permeabilized preparations of tonic type smooth muscle.

@article{Takeuchi2003EssentialRO,
  title={Essential role of ATP synthesized by creatine kinase in contraction of alpha-toxin permeabilized preparations of tonic type smooth muscle.},
  author={Tadayoshi Takeuchi and Muneyoshi Kitayama and Masahiko Kushida and Akikazu Fujita and Fumiaki Hata},
  journal={Journal of pharmacological sciences},
  year={2003},
  volume={92 4},
  pages={374-80}
}
The role of ATP newly synthesized from ADP and phosphocreatine (PC) by creatine kinase (CK) in the contraction of tonic type smooth muscle, rat femoral artery was studied, since its necessity for phasic type smooth muscle was previously shown. In alpha-toxin-permeabilized preparations obtained from rat femoral artery, Ca(2+) induced a tonic type contraction in the presence of ATP and PC. Omission of PC inhibited significantly the contraction. Treatment of the preparations with 2,4… CONTINUE READING