Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

  title={Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression},
  author={C. Neumann and D. S. Krause and C. Carman and S. Das and D. Dubey and J. L. Abraham and R. Bronson and Y. Fujiwara and S. Orkin and R. A. Etten},
  • C. Neumann, D. S. Krause, +7 authors R. A. Etten
  • Published 2003
  • Biology, Medicine
  • Nature
  • Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice lacking Prdx1 are viable and fertile but have a shortened lifespan owing to the development beginning at about 9 months of severe haemolytic anaemia and several malignant cancers… CONTINUE READING
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