Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

@article{Neumann2003EssentialRF,
  title={Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression},
  author={Carola A Neumann and Daniela S. Krause and Christopher V. Carman and Shampa Das and D. P. Dubey and J L Abraham and Roderick T Bronson and Yuko Fujiwara and Stuart H. Orkin and Richard A. Van Etten},
  journal={Nature},
  year={2003},
  volume={424},
  pages={561-565}
}
Reactive oxygen species are involved in many cellular metabolic and signalling processes and are thought to have a role in disease, particularly in carcinogenesis and ageing. We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes. Here we show that mice lacking Prdx1 are viable and fertile but have a shortened lifespan owing to the development beginning at about 9 months of severe haemolytic anaemia and several malignant cancers… Expand
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TLDR
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