Essential role for survivin in early brain development.

  title={Essential role for survivin in early brain development.},
  author={Yuying Jiang and Alain de Bruin and Hugo Caldas and Jason R. Fangusaro and John Hayes and Edward M Conway and M. L. Robinson and Rachel A. Altura},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 30},
Apoptosis is an essential process during normal neuronal development. Approximately one-half of the neurons produced during neurogenesis die before completion of CNS maturation. To characterize the role of the inhibitor of apoptosis gene, survivin, during neurogenesis, we used the Cre-loxP-system to generate mice lacking survivin in neuronal precursor cells. Conditional deletion of survivin starting at embryonic day 10.5 leads to massive apoptosis of neuronal precursor cells in the CNS… CONTINUE READING


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