Essential role for proteinase-activated receptor-2 in arthritis.

  title={Essential role for proteinase-activated receptor-2 in arthritis.},
  author={William Russell Ferrell and John C. Lockhart and Elizabeth B. Kelso and Lynette Dunning and Robin J Plevin and Stephen Earl Meek and Andrew J. H. Smith and Gary L. Hunter and John Stephen McLean and Frances McGarry and Robert Ramage and Lu Jiang and Toru Kanke and Junichi Kawagoe},
  journal={The Journal of clinical investigation},
  volume={111 1},
Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2-deficient mice, being reduced by more than fourfold compared with wild-type mice, with virtually no histological evidence of joint damage. Mice heterozygous for PAR-2 gene disruption showed an… CONTINUE READING
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