Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

@article{Takeda2007EssentialRF,
  title={Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.},
  author={Kotaro Takeda and Ann E. Cowan and G S Fong},
  journal={Circulation},
  year={2007},
  volume={116 7},
  pages={774-81}
}
BACKGROUND Prolyl hydroxylase domain (PHD) proteins, including PHD1, PHD2, and PHD3, mediate oxygen-dependent degradation of hypoxia-inducible factor (HIF)-alpha subunits. Although angiogenic roles of hypoxia-inducible factors are well known, the roles of PHDs in the vascular system remain to be established. METHODS AND RESULTS We evaluated angiogenic… CONTINUE READING