Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development

  title={Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development},
  author={Takuya Imamura and Thi My Anh Neildez and Catherine Thenevin and Andr{\'a}s P{\'a}ldi},
  journal={BMC Molecular Biology},
  pages={4 - 4}
Poly (ADP-ribosyl)ation is a covalent modification of many nuclear proteins. It has a strong chromatin modifying potential involved in DNA repair, transcription and replication. Its role during preimplantation development is unknown. We have observed strong but transient synthesis of poly ADP-ribose polymers on decondensing chromosomes of fertilized and parthenogenetically activated mouse oocytes. Inhibition of this transient upregulation with a specific enzyme inhibitor, 3-aminobenzamide, has… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
7 Extracted Citations
24 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 24 references

Similar Papers

Loading similar papers…