Essential role for oncogenic Ras in tumour maintenance

  title={Essential role for oncogenic Ras in tumour maintenance},
  author={Lynda Chin and Alice Tam and Jason Pomerantz and Michelle Wong and Jocelyn Holash and Nabeel Bardeesy and Qiong Shen and R{\'o}n{\'a}n C. O'Hagan and Joe Pantginis and Hao Zhou and James W. Horner and Carlos Cordon-Cardo and George D. Yancopoulos and Ronald A. Depinho},
Advanced malignancy in tumours represents the phenotypic end-point of successive genetic lesions that affect the function and regulation of oncogenes and tumour-suppressor genes. The established tumour is maintained through complex and poorly understood host–tumour interactions that guide processes such as angiogenesis and immune sequestration. The many different genetic alterations that accompany tumour genesis raise questions as to whether experimental cancer-promoting mutations remain… CONTINUE READING
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