Essential role for focal adhesion kinase in regulating stress hematopoiesis.

  title={Essential role for focal adhesion kinase in regulating stress hematopoiesis.},
  author={Sasidhar Vemula and Baskar Ramdas and Philip Hanneman and Joseph T. Martin and Hilary E. Beggs and Reuben Kapur},
  volume={116 20},
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that has been extensively studied in fibroblasts; however its function in hematopoiesis remains an enigma. FAK is thought to be expressed in myeloid and erythroid progenitors, and its expression is enhanced in response to cytokines such as granu-locyte macrophage colony-stimulating factor. Furthermore, bone marrow cells cultured in granulocyte macrophage colony-stimulating factor show active migration and chemoattractant-induced… CONTINUE READING