Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.

@article{Kushida2001EssentialRF,
  title={Essential role for extracellular Ca(2+) in JNK activation by mechanical stretch in bladder smooth muscle cells.},
  author={N. Kushida and Y. Kabuyama and O. Yamaguchi and Y. Homma},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={281 4},
  pages={
          C1165-72
        }
}
Mechanical stretch has been implicated in phenotypic changes as an adaptive response to stretch stress physically loaded in bladder smooth muscle cells (BSMCs). To investigate stretch-induced signaling, we examined the mitogen-activated protein kinase (MAPK) family using rat primary BSMCs. When BSMCs were subjected to sustained mechanical stretch using collagen-coated silicon membranes, activation of c-Jun NH(2)-terminal kinase (JNK) was most relevant among three subsets of MAPK family members… Expand
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  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2019
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