Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.

@article{Sicinska2006EssentialRF,
  title={Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes.},
  author={Ewa T. Sicinska and Young-mi Lee and Judith Gits and Hirokazu Shigematsu and Qunyan Yu and Vivienne I. Rebel and Yan Geng and Christopher J. Marshall and Koichi Akashi and David M Dorfman and Ivo P. Touw and Piotr Sicinski},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 21},
  pages={8052-60}
}
The proliferation of neutrophil granulocyte lineage is driven largely by granulocyte colony-stimulating factor (G-CSF) acting via the G-CSF receptors. In this study, we show that mice lacking cyclin D3, a component of the core cell cycle machinery, are refractory to stimulation by the G-CSF. Consequently, cyclin D3-null mice display deficient maturation of granulocytes in the bone marrow and have reduced levels of neutrophil granulocytes in their peripheral blood. The mutant mice are unable to… CONTINUE READING
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