Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

@article{Yamamoto2002EssentialRF,
  title={Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4},
  author={Masahiro Yamamoto and Shintaro Sato and Hiroaki Hemmi and Hideki Sanjo and Satoshi Uematsu and Tsuneyasu Kaisho and Katsuaki Hoshino and Osamu Takeuchi and Masaya Kobayashi and Takashi Fujita and Kiyoshi Takeda and Shizuo Akira},
  journal={Nature},
  year={2002},
  volume={420},
  pages={324-329}
}
Signal transduction through Toll-like receptors (TLRs) originates from their intracellular Toll/interleukin-1 receptor (TIR) domain, which binds to MyD88, a common adaptor protein containing a TIR domain. Although cytokine production is completely abolished in MyD88-deficient mice, some responses to lipopolysaccharide (LPS), including the induction of interferon-inducible genes and the maturation of dendritic cells, are still observed. Another adaptor, TIRAP (also known as Mal), has been cloned… 
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