Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis

@article{Basavannacharya2010EssentialRF,
  title={Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis},
  author={Chandrakala Basavannacharya and Paul R. Moody and Tulika K. Munshi and Nora Cronin and Nicholas H Keep and Sanjib Bhakta},
  journal={Protein & Cell},
  year={2010},
  volume={1},
  pages={1011-1022}
}
The emergence of total drug-resistant tuberculosis (TDRTB) has made the discovery of new therapies for tuberculosis urgent. The cytoplasmic enzymes of peptidoglycan biosynthesis have generated renewed interest as attractive targets for the development of new anti-mycobacterials. One of the cytoplasmic enzymes, uridine diphosphate (UDP)-MurNAc-tripeptide ligase (MurE), catalyses the addition of meso-diaminopimelic acid (m-DAP) into peptidoglycan in Mycobacterium tuberculosis coupled to the… CONTINUE READING