Essential requirement for RING finger E3 ubiquitin ligase Hakai in early embryonic development of Drosophila.

@article{Kaido2009EssentialRF,
  title={Essential requirement for RING finger E3 ubiquitin ligase Hakai in early embryonic development of Drosophila.},
  author={Masako Kaido and Housei Wada and Masayo Shindo and Shigeo Hayashi},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2009},
  volume={14 9},
  pages={
          1067-77
        }
}
Hakai is a RING finger type E3 ubiquitin ligase that is highly conserved in metazoans. Mammalian Hakai was shown to bind and ubiquitinate the intracellular domain of E-cadherin, and this activity is implicated in down-regulation of E-cadherin during v-Src-induced cellular transformation. To evaluate this model in vivo, we studied the function of the Drosophila homologue of Hakai. In cultured S2 cells, Drosophila Hakai and E-cadherin (Shotgun) formed a complex in a way distinct from the… CONTINUE READING
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Genes to Cells

  • M Kaido
  • 2009

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