Essential protective roles of reactive astrocytes in traumatic brain injury.

  title={Essential protective roles of reactive astrocytes in traumatic brain injury.},
  author={Dr. J. S. Myer and Gene G. Gurkoff and Sang Min Lee and David A. Hovda and Michael V Sofroniew},
  journal={Brain : a journal of neurology},
  volume={129 Pt 10},
Astrocytes respond to traumatic brain injury (TBI) by altered gene expression, hypertrophy and proliferation that occur in a gradated fashion in relation to the severity of the injury. Both beneficial and detrimental effects have been attributed to reactive astrocytes, but their roles after brain injury are not well understood. To investigate these roles, we determined the effects on cortical tissue of ablating reactive astrocytes after contusion injury generated by controlled cortical impact… CONTINUE READING
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