Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model.

@article{Vetelinen2007EssentialPA,
  title={Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model.},
  author={Reeta L. Vetel{\"a}inen and Arl{\`e}ne K van Vliet and Thomas Matthijs van Gulik},
  journal={Journal of gastroenterology and hepatology},
  year={2007},
  volume={22 9},
  pages={1526-33}
}
BACKGROUND AND AIM Choline deficient (CD) and methione-choline deficient (MCD) diets are rodent models for steatosis, with potentially dissimilar biochemical backgrounds. The aim of this study was to assess the metabolic and pathological derangements in rats fed CD and MCD diets. METHODS Male Wistar rats received CD or MCD diet up to 7 weeks. Nutritional status, liver histopathology, Kupffer cell-mediated inflammation and injury, oxidative stress via thiobarbituric reactive species (TBARS… CONTINUE READING