Essential involvement of interleukin‐8 (IL‐8) in acute inflammation

@article{Harada1994EssentialIO,
  title={Essential involvement of interleukin‐8 (IL‐8) in acute inflammation},
  author={Akihisa Harada and Nobuaki Sekido and Tohru Akahoshi and Takashi Wada and Naofumi Mukaida and Kouji Matsushima},
  journal={Journal of Leukocyte Biology},
  year={1994},
  volume={56}
}
Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. [...] Key Method We administered a highly specific neutralizing antibody against IL-8 in several types of acute inflammatory reactions, including lipopolysaccharide (LPS)-induced dermatitis, LPS/IL-1-induced arthritis, lung reperfusion injury, and acute immune complex-type glomerulonephritis. Anti-IL-8 treatment prevented neutrophil-dependent tissue damage as well as neutrophil infiltration in these conditions. These…Expand
Interleukin 8 Elicits Rapid Physiological Changes in Neutrophils That Are Altered by Inflammatory Conditions
TLDR
Novel mechanistic insights are provided for the interaction of IL-8 with neutrophil granulocytes and report in detail about its alteration during systemic inflammation.
Cytokine regulation of human microglial cell IL-8 production.
TLDR
Findings indicate that human microglia synthesize IL-8 in response to proinflammatory stimuli, and that anti-inflammatory cytokines down-regulate the production of this chemokine, which may have important therapeutic implications for certain central nervous system insults involving inflammation.
TNF receptor I mediates chemokine production and neutrophil accumulation in the lung following systemic lipopolysaccharide.
TLDR
Acute lung injury following systemic LPS administration is characterized by increased lung TNF-alpha production, C-X-C chemokine production, and neutrophil accumulation, which appears to be dependent upon the TNFRI receptor but not the TNFRII receptor.
IL‐8 induces a specific transcriptional profile in human neutrophils: synergism with LPS for IL‐1 production
TLDR
The effect of IL‐8 at the transcriptional level could provide a synergistic effect with microbial products for neutrophil activation and may provide a strategy to prepare for migration into tissues.
Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
TLDR
The data indicate the importance of Tpl2 in the modulation of ERK1/2 signaling involved in the IL-1β-induced development of autoimmune diseases affecting the dermal tissue, such as atopic dermatitis.
The role of leukocytes in tissue injury.
TLDR
The challenge for future investigations will need to be carefully examined: the relations between leukocyte and endothelial cell interactions, the mechanisms of activation of leukocytes and endothelium cells, and the components of the signaling pathways.
Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.
TLDR
It is reported that antagonism of PAR1 was highly effective at reducing acute neutrophil accumulation in a mouse model of LPS-induced lung inflammation, and a novel role for PAR1 and the chemokines, CCL2 and CCL7, during the early events of acute neutrophic inflammation.
Effect of polysaccharide sulfates on the production of interleukin-8 in an ex vivo model.
TLDR
It has recently been reported that acidic polysaccharides extracted from the root of Panax ginseng, stimulate IL-8 synthesis in monocyte-derived macrophages and may augment the activation and chemotaxis of neutrophils in the incidence of sepsis.
Interleukin-1, Neutrophil Elastase, and Lipopolysaccharide: Key Pro- Inflammatory Stimuli Regulating Inflammation in Cystic Fibrosis
TLDR
Two important host-derived factors with potent proinflammatory effects in CF are interleukin-1 (IL-1) and neutrophil elastase (NE) and microbial- derived factors also have importance in the CF lung, as a significant factor by which pulmonary inflammation is mediated in CF is by Pseudomonas aeruginosa infection.
Peroxynitrite mediates cytokine‐induced IL‐8 gene expression and production by human leukocytes
TLDR
It is reported that peroxynitrite (ONOO−) formed by a reaction of NO with superoxide mediates IL‐8 gene expression andIL‐8 production in IL‐1β‐ and TNF‐α‐stimulated human leukocytes in whole blood.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Essential involvement of interleukin-8 in neutrophil recruitment in rabbits with acute experimental arthritis induced by lipopolysaccharide and interleukin-1.
TLDR
This is the first paper to clearly demonstrate that IL-8 is an essential and major mediator determining whether PMN infiltration will occur in the early phase of experimental acute arthritis.
Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody.
TLDR
The data suggest the presence of an IL-8-like product in this model of lung injury, and indicate that in inflammatory lung injury that is linked to E-selectin-dependent recruitment of neutrophils in rats, antibody to humanIL-8 also blocks recruitment ofNeutrophils and thereby affords protection against lung injury.
Production of IL‐1 and IL‐1 receptor antagonist and the pathological significance in lipopolysaccharide‐induced arthritis in rabbits
TLDR
The results suggest that L PS‐initiated IL‐1 acts as a key mediator in LPS‐arthritis and that endogenous IL‐ 1 Ra may suppress a part of IL‐2 activity at the site, but its amount was too low for suppression of the produced IL‐3.
Interleukin-8 as a macrophage-derived mediator of angiogenesis.
TLDR
A function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair is suggested.
Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes.
TLDR
The data demonstrate the stimulus specific induction of NCF/IL-8 in hepatocytes and suggest that cytokine cell-to-cell communication circuits may be important in neutrophil-mediated inflammatory processes in the liver.
Role for macrophage products in endotoxin-induced polymorphonuclear leukocyte accumulation during inflammation.
TLDR
Investigation of the factors which may mediate LPS-induced PMNL accumulation in the pleural cavity and skin of rabbits concludes that PMNL infiltration induced by LPS and perhaps by Gram-negative bacteria, may be mediated in part by the secretion from tissue macrophages of factors which can recruit PMNLs from the blood.
In situ hybridization of IL‐6 in rheumatoid arthritis
TLDR
In individual RA patients tested serially after admission to hospital, serum IL‐6 was initially raised and, unexpectedly, increased with clinical improvement, and in situ hybridization of IL‐ 6 mRNA showed positive cells both in the lymphocyte‐rich aggregates and adjacent to small blood vessels.
Granulocyte chemotactic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin.
TLDR
Evidence is provided that GCP/IL-8 fulfills two important criteria for consideration as an inflammatory mediator: fast in onset, relatively short of duration, and associated with a parallel time course of plasma protein extravasation.
Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8
TLDR
Reperfusion of ischaemic lung caused neutrophil infiltration and destruction of pulmonary structure, as well as local production of IL-8, proving a causal role of locally produced IL- 8 in this model.
Monocyte-derived neutrophil chemotactic factor/interleukin-8 is a potential mediator of crystal-induced inflammation.
TLDR
It is concluded that microcrystal-induced secretion of IL-8 by mononuclear phagocytes may mediate a number of forms of crystal-induced inflammation.
...
1
2
3
4
5
...