Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?

  title={Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?},
  author={Richard J Johnson and Mark S. Segal and Titte M Srinivas and A. Ahsan Ejaz and Wei Mu and Carlos Guilhermo Piscoya Roncal and L Gabriela S{\'a}nchez-Lozada and Michael Gersch and Bernardo Rodriguez-Iturbe and Duk-Hee Kang and Jaime Acosta},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={16 7},
Hypertension and hypertension-associated ESRD are epidemic in society. The mechanisms responsible for renal progression in mild to moderate hypertension and those groups most at risk need to be identified. Historic, epidemiologic, clinical, and experimental studies on the pathogenesis of hypertension and hypertension-associated renal disease are reviewed and an overview/hypothesis for the mechanisms involved in renal progression is presented. There is increasing evidence that hypertension may… CONTINUE READING


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