Essential glycan-dependent interactions optimize MHC class I peptide loading

  • Pamela A. Wearscha, David R. Peapera, Peter Cresswella
  • Published 2011
In this study we sought to better understand the role of the glycoprotein quality control machinery in the assembly of MHC class I molecules with high-affinity peptides. The lectin-like chaperone calreticulin (CRT) and the thiol oxidoreductase ERp57 participate in the final step of this process as part of the peptide-loading complex (PLC). We provide… CONTINUE READING