Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines.

@article{Duplantis2010EssentialGF,
  title={Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines.},
  author={Barry N. Duplantis and Milan Osusky and Crystal L Schmerk and Darrell R Ross and Catharine M. Bosio and Francis E Nano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 30},
  pages={13456-60}
}
All bacteria share a set of evolutionarily conserved essential genes that encode products that are required for viability. The great diversity of environments that bacteria inhabit, including environments at extreme temperatures, place adaptive pressure on essential genes. We sought to use this evolutionary diversity of essential genes to engineer bacterial pathogens to be stably temperature-sensitive, and thus useful as live vaccines. We isolated essential genes from bacteria found in the… CONTINUE READING
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