Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.

@article{Jordan2002EssentialGA,
  title={Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.},
  author={I. King Jordan and Igor B. Rogozin and Yuri I. Wolf and Eugene V. Koonin},
  journal={Genome research},
  year={2002},
  volume={12 6},
  pages={962-8}
}
The "knockout-rate" prediction holds that essential genes should be more evolutionarily conserved than are nonessential genes. This is because negative (purifying) selection acting on essential genes is expected to be more stringent than that for nonessential genes, which are more functionally dispensable and/or redundant. However, a recent survey of evolutionary distances between Saccharomyces cerevisiae and Caenorhabditis elegans proteins did not reveal any difference between the rates of… CONTINUE READING
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