Essential fatty acids and human brain.

@article{Chang2009EssentialFA,
  title={Essential fatty acids and human brain.},
  author={Chia-Yu Chang and Der-Shin Ke and Jen-Yin Chen},
  journal={Acta neurologica Taiwanica},
  year={2009},
  volume={18 4},
  pages={
          231-41
        }
}
The human brain is nearly 60 percent fat. We've learned in recent years that fatty acids are among the most crucial molecules that determine your brain's integrity and ability to perform. Essential fatty acids (EFAs) are required for maintenance of optimal health but they can not synthesized by the body and must be obtained from dietary sources. Clinical observation studies has related imbalance dietary intake of fatty acids to impaired brain performance and diseases. Most of the brain growth… 
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References

SHOWING 1-10 OF 64 REFERENCES
Nutrition in brain development and aging: role of essential fatty acids.
The essential fatty acids (EFAs), particularly the n-3 long-chain polyunsaturated fatty acids (LCPs), are important for brain development during both the fetal and postnatal period. They are also
Essential fatty acids, DHA and human brain
TLDR
Intention of EFAs and DHA during preschool years may also have a beneficial role in the prevention of attention deficit hyperactivity disorder (ADHD) and enhancing learning capability and academic performance.
Essential fatty acids and the brain: From infancy to aging
Fatty Acids and Brain Peptides
Dietary (n-3) fatty acids and brain development.
  • S. Innis
  • Psychology, Medicine
    The Journal of nutrition
  • 2007
TLDR
A better understanding of development and age-specific changes in DHA transfer and function in the developing brain may provide important insight into the role of DHA in developmental disorders in infants and children, as well as at other stages of the lifespan.
Diet, Lipids and Brain Development
TLDR
The use of particular lipids in human nutrition must be carefully screened for possible effects on brain development, as it is becoming more evident that this process is influenced by dietary lipids.
Role of Long-chain Polyunsaturated Fatty Acids in the First Year of Life
  • C. Agostoni
  • Medicine
    Journal of pediatric gastroenterology and nutrition
  • 2008
The 2 most abundant long-chain polyunsaturated fatty acids (LCPUFAs) in the brain are docosahexaenoic acid (DHA) and arachidonic acid (ARA), where they have a functional and structural role in infant
Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants.
TLDR
The higher concentration of DHA in brains of breast- fed infants may explain the improved neurodevelopment reported in breast-fed compared with formula-fed infants.
Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia
Docosahexaenoic acid and the aging brain.
TLDR
Current understanding of the interactions of DHA and NPD1 on betaAPP processing and Abeta peptide signaling is reviewed and how this contributes to oxidative and pathogenic processes characteristic of aging and AD pathology is reviewed.
...
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