Essential fatty acids, DHA and human brain

@article{Singh2005EssentialFA,
  title={Essential fatty acids, DHA and human brain},
  author={Meharban Singh},
  journal={The Indian Journal of Pediatrics},
  year={2005},
  volume={72},
  pages={239-242}
}
  • Meharban Singh
  • Published 1 March 2005
  • Medicine
  • The Indian Journal of Pediatrics
Essential fatty acids cannot be synthesized in the body but they are required for maintenance of optimal health. There are two classes of polyunsaturated fatty acids (PUFAs)- omega-6 and omega-3. The parent omega-6 fatty acid, linoleic acid (LA) is desaturated in the body to form arachidonic acid while parent omega-3 fatty acid, alpha-linolenic acid (ALA) is desaturated by microsomal enzyme system through a series of metabolic steps to form eicosapentaenoic acid (EPA) and decosahexaenoic acid… 
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References

SHOWING 1-10 OF 26 REFERENCES
Essential fatty acids in early life: structural and functional role
TLDR
Clinical trials convincingly support LCPUFA supplementation of preterm infant formulations and possibly term formula to mimic human milk composition and an associated improvement in visual function in formula-fed premature infants to match that of human milk-fed infant.
Essential Fatty Acids and the Brain
  • M. Haag
  • Biology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2003
TLDR
Intervention trials in human subjects show that omega-3 fatty acids have possible positive effects in the treatment of various psychiatric disorders, but more data are needed to make conclusive directives in this regard.
Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications.
TLDR
Total n-3 requirements may be higher for vegetarians than for nonvegetarians, as vegetarians must rely on conversion of ALA to EPA and DHA, although the response is generally less for ALA than for EPA andDHA.
Requirements of dietary fats to meet nutritional needs & prevent the risk of atherosclerosis--an Indian perspective.
TLDR
To arrive at the fat requirements for Indians, invisible fat and fatty acid compositions were determined in commonly consumed foods and the use of more than one oil is recommended, however, it is necessary to evaluate the long-term health benefits of the recommended oil combinations before permitting commercial preparation and endorsing health claims.
Physiological compartmental analysis of !-linolenic acid metabolism in adult humans
A physiological compartmental model of ! -linolenic acid metabolism was derived from the plasma concentration-time curves for d5-18:3n-3, d5-20:5n-3, d5-22:5n-3, and d5-22:6n-3 in eight healthy
Maternal dietary fish oil enriches docosahexaenoate levels in brain subcellular fractions of offspring
TLDR
The inclusion of preformed DHA and EPA in the maternal diet provides an effective means to enrich these fatty acids in developing brains.
Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder.
TLDR
A subgroup of ADHD subjects reporting many symptoms indicative of EFA deficiency (L-ADHD) had significantly lower proportions of plasma arachidonic acid and docosahexaenoic acid than did ADHD subjects with few such symptoms or control subjects, and subjects with lower compositions of total n-3 fatty acids had significantly more behavioral problems.
Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition.
TLDR
It is demonstrated that DHA in the diet has a strong, specific and dose-dependent effect on breast milk DHA.
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