Essential fatty acids, DHA and human brain

  title={Essential fatty acids, DHA and human brain},
  author={Meharban Singh},
  journal={The Indian Journal of Pediatrics},
Essential fatty acids cannot be synthesized in the body but they are required for maintenance of optimal health. There are two classes of polyunsaturated fatty acids (PUFAs)- omega-6 and omega-3. The parent omega-6 fatty acid, linoleic acid (LA) is desaturated in the body to form arachidonic acid while parent omega-3 fatty acid, alpha-linolenic acid (ALA) is desaturated by microsomal enzyme system through a series of metabolic steps to form eicosapentaenoic acid (EPA) and decosahexaenoic acid… Expand
The role of the ω-3 fatty acid DHA in the human life cycle.
In childhood, ω-3s have been shown to contribute to ongoing cognitive development and may be involved in metabolic programming of bone turnover and adipogenesis, and may also play important roles in adult neurophysiology and disease prevention. Expand
Essential fatty acids and human brain.
The goal of this review is to give a new understanding of how EFAs determine the authors' brain's integrity and performance, and to recall the neuropsychiatric disorders that may be influenced by them. Expand
Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet.
Consumption of dietary flaxseed appears to be an effective means to increase ALA content in body tissues, but the degree will depend upon the tissues examined. Expand
Omega-3 Essential Fatty Acids Modulate Initiation and Progression of Neurodegenerative Disease
It is concluded that DHA-derived NPD1 regulation targets upstream events of brain cell apoptosis, as well as neuro-inflammatory signaling, promoting and maintaining cellular homeostasis, and restoring neural and retinal cell integrity. Expand
The effects of omega 3 fatty acid supplementation on brain tissue oxidative status in aged wistar rats.
Investigation of the effects of dietary omega-3 fatty acid supplementation on levels of lipid peroxidation and oxidant/antioxidant status of brain tissue in aged (24 months old) Wistar rats showed changes in oxidative/ant antioxidant balance are a result of EPA and DHA effects on lipids and enzymes of antioxidative system. Expand
Fatty acids of human milk - a review.
  • R. Bobiński, J. Bobinska
  • Medicine, Biology
  • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 2020
The composition of human milk is the result of the evolution of mammals over millions of years. Among the most important components of milk are fatty acids. Approximately 85% are saturated andExpand
A Comprehensive Review of Chemistry, Sources and Bioavailability of Omega-3 Fatty Acids
A broad and relatively complete cross-section of knowledge is presented about omega-3 monounsaturated fatty acids, polyunsaturates, and an outline of their modifications, because all these subgroups undoubtedly play an important role in the function of organisms. Expand
Influence of omega-3 fatty acids and monounsaturated fats in liver diseases
Abstract Generally, fatty acids (FA) are classified into saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), and polyunsaturated fatty acids (PUFA). Different fatty acids of the sameExpand
A brief review of physiological roles, plant resources, synthesis, purification and oxidative stability of Alpha-linolenic Acid
Alpha-linolenic acid (ALA) is a polyunsaturated fatty acid (PUFA) comprising of 18 carbon atoms and three double bonds. Because the first double bond counted from the methyl terminus, is at positionExpand
Prevention of Oxidative Stress by Omega-3 Fatty Acids in the Brain
Oxidative stress and inflammation are the major mechanisms that contribute to the pathogenesis of neurotraumatic, neurodegenerative, and neuropsychiatric diseases. Two major families of essentialExpand


Essential fatty acids in early life: structural and functional role
Clinical trials convincingly support LCPUFA supplementation of preterm infant formulations and possibly term formula to mimic human milk composition and an associated improvement in visual function in formula-fed premature infants to match that of human milk-fed infant. Expand
Essential Fatty Acids and the Brain
  • M. Haag
  • Chemistry, Medicine
  • Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2003
Intervention trials in human subjects show that omega-3 fatty acids have possible positive effects in the treatment of various psychiatric disorders, but more data are needed to make conclusive directives in this regard. Expand
Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements.
Developmental changes and estimates of fatty acid incorporation into whole brain and cerebellum are quantitatively relevant to estimation of fatty acids requirements of the low birth weight neonate. Expand
Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age.
The hypothesis was that maternal intake of DHA during pregnancy and lactation is marginal and that high intake of this fatty acid would benefit the child, and the effect of supplementing pregnant and lactating women with very-long- chain n-3 polyunsaturated fatty acids (PUFAs; cod liver oil) on mental development of the children, compared with maternal supplementation with long-chain n-6 PUFAs (corn oil). Expand
Relationship between fatty acid accretion, membrane composition, and biologic functions.
Whether diet could be used to induce formation of membrane structures that are more resistant to specific insults that cause degeneration of brain structural material, to ensure optimal functional compositions, or to reverse degenerative changes that occur in neural membrane structure and function is pondered. Expand
Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications.
Total n-3 requirements may be higher for vegetarians than for nonvegetarians, as vegetarians must rely on conversion of ALA to EPA and DHA, although the response is generally less for ALA than for EPA andDHA. Expand
Requirements of dietary fats to meet nutritional needs & prevent the risk of atherosclerosis--an Indian perspective.
To arrive at the fat requirements for Indians, invisible fat and fatty acid compositions were determined in commonly consumed foods and the use of more than one oil is recommended, however, it is necessary to evaluate the long-term health benefits of the recommended oil combinations before permitting commercial preparation and endorsing health claims. Expand
Physiological compartmental analysis of !-linolenic acid metabolism in adult humans
A physiological compartmental model of ! -linolenic acid metabolism was derived from the plasma concentration-time curves for d5-18:3n-3, d5-20:5n-3, d5-22:5n-3, and d5-22:6n-3 in eight healthyExpand
Maternal dietary fish oil enriches docosahexaenoate levels in brain subcellular fractions of offspring
The inclusion of preformed DHA and EPA in the maternal diet provides an effective means to enrich these fatty acids in developing brains. Expand
Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder.
A subgroup of ADHD subjects reporting many symptoms indicative of EFA deficiency (L-ADHD) had significantly lower proportions of plasma arachidonic acid and docosahexaenoic acid than did ADHD subjects with few such symptoms or control subjects, and subjects with lower compositions of total n-3 fatty acids had significantly more behavioral problems. Expand