Essential dynamics of helices provide a functional classification of EF-hand proteins.

@article{Capozzi2007EssentialDO,
  title={Essential dynamics of helices provide a functional classification of EF-hand proteins.},
  author={Francesco Capozzi and Claudio Luchinat and Cristian Micheletti and F. Pontiggia},
  journal={Journal of proteome research},
  year={2007},
  volume={6 11},
  pages={4245-55}
}
Low energy modes have been calculated for the largest possible number of available representatives (>150) of EF-hand domains belonging to different members of the calcium-binding EF-hand protein superfamily. These proteins are the major actors in signal transduction. The latter, in turn, relies on the dynamical properties of the systems, in particular on the relative movements of the four helices characterizing each EF-hand domain upon calcium binding. The peculiar structural and dynamical… CONTINUE READING