Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain.

Abstract

Transgenic mice were generated with a transgene containing the 211-base pair (bp) enhancer and 0.4 kilobase pairs of 5'-flanking DNA of the uncoupling protein (ucp) gene. Expression of this transgene was restricted to brown adipose tissue and was inducible by cold exposure or treatment of transgenic mice by norepinephrine, retinoic acid (RA), or CL-316,243… (More)

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@article{Larose1996EssentialCE, title={Essential cis-acting elements in rat uncoupling protein gene are in an enhancer containing a complex retinoic acid response domain.}, author={M. Larose and Anne-Marie Cassard-Doulcier and C. Fleury and François Serra and Odette Champigny and Fr{\'e}d{\'e}ric Bouillaud and Daniel Ricquier}, journal={The Journal of biological chemistry}, year={1996}, volume={271 49}, pages={31533-42} }