Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis.

@article{Chen2002EssentialAR,
  title={Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis.},
  author={Jennifer C. J. Chen and Rageshree Ramachandran and David J Goldhamer},
  journal={Developmental biology},
  year={2002},
  volume={245 1},
  pages={
          213-23
        }
}
Transgenic analyses have defined two MyoD enhancers in mammals, the core enhancer and distal regulatory region (DRR); these enhancers exhibit complementary activities and together are sufficient to recapitulate MyoD expression in developing and mature skeletal muscle. DRR activity is restricted to differentiated muscle and persists postnatally, suggesting an important role in maintaining MyoD expression in myocytes and muscle fibers. Here, we use targeted mutagenesis in the mouse to define… CONTINUE READING
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