Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest.

@article{PaddonJones2004EssentialAA,
  title={Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest.},
  author={Douglas Paddon-Jones and Melinda Sheffield-Moore and Randall James Urban and Arthur P. Sanford and Asle A Aarsland and Robert R. Wolfe and Arny A. Ferrando},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 9},
  pages={4351-8}
}
We determined whether essential amino acid and carbohydrate supplementation could offset the catabolic response to prolonged inactivity. Major outcome measures included mixed muscle fractional synthetic rate (FSR), phenylalanine net balance, lean leg mass, and leg extension strength. On d 1 and 28, vastus lateralis muscle biopsies and femoral arterio-venous blood samples were obtained during a primed constant infusion of l-[ring-(2)H(5)]phenylalanine. Net balance and FSR were calculated over 16… CONTINUE READING
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