Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis

@article{Awasaki2006EssentialRO,
  title={Essential Role of the Apoptotic Cell Engulfment Genes draper and ced-6 in Programmed Axon Pruning during Drosophila Metamorphosis},
  author={Takeshi Awasaki and Ryoko Tatsumi and Kuniaki Takahashi and Kunizo Arai and Yoshinobu Nakanishi and Ryu Ueda and Kei Ito},
  journal={Neuron},
  year={2006},
  volume={50},
  pages={855-867}
}
Axon pruning is a common phenomenon in neural circuit development. Previous studies demonstrate that the engulfing action of glial cells is essential in this process. The underlying molecular mechanisms, however, remain unknown. We show that draper (drpr) and ced-6, which are essential for the clearance of apoptotic cells in C. elegans, function in the glial engulfment of larval axons during Drosophila metamorphosis. The drpr mutation and glia-specific knockdown of drpr and ced-6 by RNA… CONTINUE READING

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