Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation

@article{Madrakhimov2018EssentialRO,
  title={Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation},
  author={S. Madrakhimov and J. Y. Yang and Ha Yan Park and T. K. Park},
  journal={Lasers in Medical Science},
  year={2018},
  volume={34},
  pages={1019-1029}
}
  • S. Madrakhimov, J. Y. Yang, +1 author T. K. Park
  • Published 2018
  • Chemistry, Medicine
  • Lasers in Medical Science
  • This study assessed the role of mechanistic target of rapamycin (mTOR) pathway in the human adult retinal pigment epithelial (ARPE) cell response after laser photocoagulation (LP). The effect of mTOR inhibition on ARPE-19 cell was investigated by rapamycin treatment after LP. Cell viability and proliferation were explored using MTT and EdU assays, respectively. The expression of mTOR-related proteins and epithelial-mesenchymal transition (EMT) markers was verified by Western blot. Rapamycin… CONTINUE READING

    References

    SHOWING 1-10 OF 46 REFERENCES
    Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF, PDGF and PlGF
    • 30
    • PDF
    PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
    • 82
    • Highly Influential
    Adeno-Associated Viral Vector-Mediated mTOR Inhibition by Short Hairpin RNA Suppresses Laser-Induced Choroidal Neovascularization
    • 13