Essential Role of Pepsin in Pathogenesis of Acid Reflux Esophagitis in Rats

@article{Nagahama2006EssentialRO,
  title={Essential Role of Pepsin in Pathogenesis of Acid Reflux Esophagitis in Rats},
  author={K. Nagahama and M. Yamato and H. Nishio and K. Takeuchi},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={51},
  pages={303-309}
}
Pepsin, a protease activated by gastric acid, is a component of the refluxate, yet the role of pepsin in the pathogenesis of reflux esophagitis has not been well studied. In the present study, we examined the effect of pepstatin, a specific inhibitor of pepsin, on acid reflux esophagitis. Acid reflux esophagitis was induced in rats by ligating both the pylorus and the forestomach for 3 or 4 hr. Pepstatin, ecabet Na (the anti-ulcer drug), and L-glutamine were administered intragastrically after… Expand
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