Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

@article{Appel2008EssentialRO,
  title={Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly},
  author={Nicole Appel and Margarita Zayas and Sven Miller and Jacomine Krijnse-Locker and Torsten Schaller and Peter Friebe and Stephanie Kallis and Ulrike Engel and Ralf Bartenschlager},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={697 - 715}
}
Persistent infection with the hepatitis C virus (HCV) is a major risk factor for the development of liver cirrhosis and hepatocellular carcinoma. With an estimated about 3% of the world population infected with this virus, the lack of a prophylactic vaccine and a selective therapy, chronic hepatitis C currently is a main indication for liver transplantation. The establishment of cell-based replication and virus production systems has led to first insights into the functions of HCV proteins… CONTINUE READING
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