Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins

@article{Fiumara2010EssentialRO,
  title={Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins},
  author={Ferdinando Fiumara and Luana Fioriti and Eric R Kandel and Wayne A. Hendrickson},
  journal={Cell},
  year={2010},
  volume={143},
  pages={1121-1135}
}
The functional switch of glutamine/asparagine (Q/N)-rich prions and the neurotoxicity of polyQ-expanded proteins involve complex aggregation-prone structural transitions, commonly presumed to be forming β sheets. By analyzing sequences of interaction partners of these proteins, we discovered a recurrent presence of coiled-coil domains both in the partners and in segments that flank or overlap Q/N-rich and polyQ domains. Since coiled coils can mediate protein interactions and multimerization, we… CONTINUE READING

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